The 2025 NFL season is packed with betting opportunities, from season-long win totals to individual player props. Whether you're a futures-focused bettor or someone who prefers specific markets, this guide provides a comprehensive overview of the best wagers for every team.

Key Betting Picks

Arizona Cardinals

• OVER 8.5 wins (-125): Arizona’s defense was among the best last season, and with Kyler Murray and Marvin Harrison Jr., they could surprise in the NFC West.
• Trey McBride OVER 4.5 receiving TDs (-110): McBride had just two TDs last season despite 111 receptions. Expect positive regression.

Atlanta Falcons

• Michael Penix Jr. to lead NFL in passing yards (+2500): If Penix Jr. lives up to the hype, this offense could be explosive.
• Drake London to lead NFL in receiving yards (+2200): London has the potential to be a top receiver if the Falcons play at a fast pace.

Baltimore Ravens

• Ravens to win AFC North (-160): With an MVP-caliber QB and a strong defense, Baltimore is a top contender.
• Ravens to lead league in scoring (+800): The offense, led by Todd Monken, could be the most potent in the NFL.

Buffalo Bills

• Bills OVER 11.5 wins (-155): Josh Allen’s consistency gives Buffalo a high floor, and a light schedule should help them surpass this total.
• James Cook UNDER 8.5 RUSHING TDs (+100): Cook is unlikely to repeat his 16-TD season from 2024.

Carolina Panthers

• Panthers OVER 6.5 wins (-135): Bryce Young showed promise late in 2024, and with added weapons, Carolina could improve.
• Week 1 Panthers-Jaguars total points UNDER 46.5 (-115): Expect a defensive battle in the season opener.

Additional Insights

Chicago Bears

• Caleb Williams OVER 3,450.5 passing yards (-130): With improved coaching and personnel, Williams is set for a breakout year.

Cincinnati Bengals

• Bengals UNDER 9.5 wins (+105): Questions on defense could lead to another missed playoff berth.

Cleveland Browns

• Shedeur Sanders OVER 600.5 passing yards (-115): Sanders could get a chance to prove himself in a rebuilding year.

Dallas Cowboys

• Cowboys OVER 7.5 wins (-145): Dak Prescott’s track record suggests Dallas will be competitive.

Denver Broncos

• Broncos OVER 9.5 wins (+100): Bo Nix’s surprising rookie campaign has many bullish on Denver’s chances.

Detroit Lions

• Lions UNDER 10.5 wins (-130): Coaching changes could lead to some regression.

Green Bay Packers

• Packers OVER 9.5 wins (-115): Jordan Love’s arm talent and Matt LaFleur’s coaching make Green Bay a contender.

Houston Texans

• Nico Collins 1,250+ receiving yards (+130): Collins is poised for a big year in Houston’s offense.

Indianapolis Colts

• Anthony Richardson Sr. to win Comeback Player of the Year (+3500): Richardson’s health could lead to a breakout season.

Jacksonville Jaguars

• Jaguars UNDER 7.5 wins (+100): Questions on both sides of the ball could limit Jacksonville’s success.

Kansas City Chiefs

• Chiefs UNDER 11.5 wins (-125): Some regression is expected after a dominant 2024.

Las Vegas Raiders

• Brock Bowers to record 1,000+ receiving yards (+105): Bowers is set for another big year with improved coaching.

Los Angeles Chargers

• Omarion Hampton OVER 825.5 rushing yards (-115): Hampton could be a key player in the Chargers’ offense.

Los Angeles Rams

• Kyren Williams UNDER 950.5 rushing yards (+100): The Rams may reduce Williams’ workload in 2025.

Miami Dolphins

• Dolphins UNDER 8.5 wins (-185): Defensive concerns could limit Miami’s success.

Minnesota Vikings

• Vikings UNDER 8.5 wins (+130): J.J. McCarthy’s inexperience could lead to some struggles.

New England Patriots

• Patriots UNDER 8.5 wins (-120): A big jump in wins may be too much to ask for in 2025.

New Orleans Saints

• Saints UNDER 5.5 wins (-150): A bleak QB situation could lead to a tough season.

New York Giants

• Giants UNDER 5.5 wins (-135): A brutal schedule could limit New York’s success.

New York Jets

• Jets OVER 5.5 wins (-140): A strong defense and offensive line could keep the Jets competitive.

Philadelphia Eagles

• Eagles to win NFC East (-160): The defending champs are the team to beat in the NFC.

Pittsburgh Steelers

• Steelers OVER 8.5 wins (-120): Mike Tomlin’s track record suggests Pittsburgh will be competitive.

San Francisco 49ers

• Christian McCaffrey OVER 7.5 rushing TDs (-105): If healthy, McCaffrey could lead the NFL in touchdowns.

Seattle Seahawks

• Kenneth Walker III OVER 6.5 rushing TDs (-105): Walker is one of the most dynamic RBs in the league.

Tampa Bay Buccaneers

• Buccaneers UNDER 9.5 wins (-120): Baker Mayfield’s TD regression could lead to fewer wins.

Tennessee Titans

• Titans OVER 5.5 wins (-145): Cameron Ward’s talent could lead to a surprising season.

Washington Commanders

• Commanders UNDER 9.5 wins (+100): A tougher schedule could limit Washington’s success.

Conclusion

The 2025 NFL season offers a wide range of betting opportunities. Whether you’re looking at win totals, player props, or futures, this guide provides a solid starting point for your betting strategy. All odds are current as of publication time and courtesy of ESPN BET.