2025 NFL Week 1 Betting Odds and Key Matchups: Full Schedule Analysis

The 2025 NFL season is set to kick off with an exciting Week 1 schedule, and the betting odds are already generating buzz among fans and analysts alike. Here’s a comprehensive breakdown of the opening games, key matchups, and betting lines to watch.

Season Opener: Eagles vs. Cowboys

The defending Super Bowl champions, the Philadelphia Eagles, will start their title defense against the Dallas Cowboys on Thursday, September 4. The Eagles are favored by 7 points, with a money line of -300, while the Cowboys are at +250. The total points line is set at 46.5.

Highlighted Matchups

Kansas City Chiefs vs. Los Angeles Chargers: The Chiefs are slight favorites at -2.5, with a money line of -155. This game will be played in São Paulo, Brazil, marking an exciting international showdown.
Baltimore Ravens vs. Buffalo Bills: This Sunday night game features the highest points total of Week 1 at 51.5. The Bills are favored by 1.5 points at home.
Detroit Lions vs. Green Bay Packers: A classic NFC North rivalry kicks off at Lambeau Field, with the Lions favored by 1.5 points.

Key Betting Trends

Washington Commanders (-7.5) vs. New York Giants: The Commanders have the largest spread of Week 1, favored by 7.5 points.
Eleven Games with Tight Spreads: Over half of the Week 1 games have spreads of a field goal or less, indicating highly competitive matchups.

International Games

The NFL continues its global expansion with games in Dublin, London, Berlin, and Madrid. Notable international matchups include:

Minnesota Vikings vs. Pittsburgh Steelers in Dublin on September 28.
Denver Broncos vs. New York Jets in London on October 12.

Betting Tips

Look for Value in Underdogs: With so many tight spreads, underdogs like the Cowboys (+250) and Giants (+300) could offer significant value.
Monitor Line Movements: Odds can shift as game day approaches, so stay updated for the best betting opportunities.

For the latest odds and expert analysis, visit ESPN BET.

Full Week 1 Schedule

Date	Matchup	Spread	Money Line	Total
Thu, Sept 4	Cowboys at Eagles	Eagles -7	Eagles -300	46.5
Fri, Sept 5	Chiefs at Chargers	Chiefs -2.5	Chiefs -155	44.5
Sun, Sept 7	Giants at Commanders	Commanders -7.5	Commanders -400	45.5
Sun, Sept 7	Buccaneers at Falcons	Buccaneers -1.5	Buccaneers -135	48.5
Sun, Sept 7	Panthers at Jaguars	Jaguars -2.5	Jaguars -165	45.5
Sun, Sept 7	Dolphins at Colts	Colts -1	Colts -120	45.5
Sun, Sept 7	Raiders at Patriots	Patriots -2	Patriots -135	43.5
Sun, Sept 7	Steelers at Jets	Steelers -2.5	Steelers -155	39.5
Sun, Sept 7	Bengals at Browns	Bengals -5	Bengals -240	44.5
Sun, Sept 7	Cardinals at Saints	Cardinals -4.5	Cardinals -195	41.5
Sun, Sept 7	49ers at Seahawks	49ers -1.5	49ers -125	45.5
Sun, Sept 7	Titans at Broncos	Broncos -7	Broncos -320	41.5
Sun, Sept 7	Lions at Packers	Lions -1.5	Lions -115	49.5
Sun, Sept 7	Texans at Rams	Rams -2.5	Rams -145	46.5
Mon, Sept 8	Vikings at Bears	Bears -1	Bears -110	45.5