2025 Fantasy Football Draft Guide: Perfect Picks for Every Round in a 12-Team League
Mike Clay's ultimate guide to the 2025 fantasy football draft, featuring round-by-round picks and strategies for a 12-team league.

Fantasy football drafts are all about maximizing value while securing those special players who can elevate your team. Whether it’s a breakout tight end, a sleeper running back, or a rising star wide receiver, these players add excitement and potential to your roster. Here’s a round-by-round breakdown of the ideal picks for a 12-team league in 2025, based on Mike Clay’s expert analysis.
Round 1: Best Available Wide Receiver or Bijan Robinson
In the first round, securing an elite wide receiver like Justin Jefferson, CeeDee Lamb, or Amon-Ra St. Brown is often the best move. However, if you land a top-two pick, Bijan Robinson is the ultimate prize. His combination of youth, talent, and workload makes him a tier above other running backs.
Round 2: Jonathan Taylor or Best Running Back Available
If you miss out on Robinson, Jonathan Taylor is a solid second-round option. Despite the Colts' QB concerns, Taylor remains a feature back with significant upside. Other enticing options include De'Von Achane and Kyren Williams.
Round 3: Trey McBride or Top Tight End
Targeting a top tight end like Trey McBride or Brock Bowers in the third round can give you a significant edge. McBride’s high target volume and potential for a heavy workload make him a valuable pick.
Round 4: Elite Dual-Threat Quarterbacks
This year, elite dual-threat QBs like Lamar Jackson, Josh Allen, and Jalen Hurts are available as late as the fourth round. Their rushing contributions provide a significant fantasy advantage.
Round 5: James Conner or Reliable Veterans
James Conner is a reliable option in the fifth round, offering consistent production and a high floor. Other solid picks include D'Andre Swift and DK Metcalf.
Round 6: TreVeyon Henderson or Breakout Candidates
Rookie TreVeyon Henderson has the potential to be a significant contributor in the Patriots' offense. Other breakout candidates include Calvin Ridley and George Pickens.
Middle Rounds: Depth and Upside
Rounds 7-10 are about filling gaps and adding depth. Players like Jaylen Waddle, Rome Odunze, and Michael Pittman Jr. offer both upside and reliability.
Late Rounds: High-Ceiling Fliers
In the later rounds, target high-upside players like Colston Loveland, Jayden Higgins, and Keon Coleman. These players can provide significant value if they break out.
Final Rounds: Kicker and Defense
If your league requires a kicker and defense, wait until the final rounds. Focus on streaming options and matchups rather than reaching for top-tier defenses.
Conclusion
This draft guide is designed to help you build a championship-caliber team in 2025. Remember, flexibility and adaptability are key. Use this as a foundation, but always be ready to adjust based on how your draft unfolds.